Nutritional Science & Toxicology

Jen-Chyan Wally Wang

Assistant Professor
Ph.D  Molecular Physiology    Vanderbilt University, 1998

Morgan Hall #3104
room 315
Berkeley, California 94720-3104
office: 510-643-1039   lab: 510-643-1039   fax:  510-642-0535

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  Dr. Jen-Chyan Wally  Wang portrait

Mechanisms of glucocorticoid receptor-regulated metabolism

The long-term goal of my research is to elucidate mechanisms underlying regulation of energy homeostasis. Abnormal energy metabolism is associated with various diseases, including diabetes, obesity and cancer. My current studies will encompass fundamental investigation of physiological processes and novel approaches to therapeutic intervention. I will focus on a single regulatory pathway, glucocorticoid signaling, applying a combinatorial approach, including biochemistry, genetics, chemistry and physiology, to dissect its function in metabolic regulation.

Recent publications

Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto KR.Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity.Genes Dev. 2006 Mar 15;20(6):689-99.

Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR. Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603-8. Epub 2004 Oct 22.

Wang JC, Walker A, Blackwell TK, Yamamoto KR. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004 Jul 9;279(28):29270-7. Epub 2004 Apr 8.

Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ, Yamamoto KR. Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13845-50. Epub 2003 Nov 14.

Recent Teaching

98 - Directed Group Study
99 - Supervised Independent Study and Research
110 - Toxicology
190 - Introduction to Research in Nutritional Sciences
H196 - Honors Research
198 - Directed Group Study
199 - Supervised Independent Study and Research
299 - Nutritional Sciences and Toxicology Research

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