The long-term goal of my research is to elucidate mechanisms underlying regulation of energy homeostasis. Abnormal energy metabolism is associated with various diseases, including diabetes, obesity and cancer. My current studies will encompass fundamental investigation of physiological processes and novel approaches to therapeutic intervention. I will focus on a single regulatory pathway, glucocorticoid signaling, applying a combinatorial approach, including biochemistry, genetics, chemistry and physiology, to dissect its function in metabolic regulation.
Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto KR.Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity.Genes Dev. 2006 Mar 15;20(6):689-99.
Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR. Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603-8. Epub 2004 Oct 22.
Wang JC, Walker A, Blackwell TK, Yamamoto KR. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004 Jul 9;279(28):29270-7. Epub 2004 Apr 8.
Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ, Yamamoto KR. Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13845-50. Epub 2003 Nov 14.